Evaluation of salivary acetylcholinesterase and pseudocholinesterase in patients with Alzheimer's disease: A case-control study.
Identifieur interne : 000065 ( Main/Exploration ); précédent : 000064; suivant : 000066Evaluation of salivary acetylcholinesterase and pseudocholinesterase in patients with Alzheimer's disease: A case-control study.
Auteurs : Fatemeh Ahmadi-Motamayel [Iran] ; Mohammad Taghi Goodarzi [Iran] ; Shabnam Tarazi [Iran] ; Mehrangiz Vahabian [Iran]Source :
- Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry [ 1754-4505 ] ; 2019.
Descripteurs français
- KwdFr :
- Acetylcholinesterase (métabolisme), Adulte d'âge moyen (MeSH), Butyrylcholine esterase (métabolisme), Enquêtes et questionnaires (MeSH), Femelle (MeSH), Humains (MeSH), Maladie d'Alzheimer (enzymologie), Mâle (MeSH), Salive (enzymologie), Sujet âgé (MeSH), Sujet âgé de 80 ans ou plus (MeSH), Études cas-témoins (MeSH).
- MESH :
- enzymologie : Maladie d'Alzheimer, Salive.
- métabolisme : Acetylcholinesterase, Butyrylcholine esterase.
- Adulte d'âge moyen, Enquêtes et questionnaires, Femelle, Humains, Mâle, Sujet âgé, Sujet âgé de 80 ans ou plus, Études cas-témoins.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Acetylcholinesterase, Butyrylcholinesterase.
- enzymology : Alzheimer Disease, Saliva.
- Aged, Aged, 80 and over, Case-Control Studies, Female, Humans, Male, Middle Aged, Surveys and Questionnaires.
Abstract
AIM
The aim of this study was to evaluate acetylcholinesterase (AChE) and pseudocholinesterase (PChE) in whole saliva in patients with Alzheimer's disease (AD) and in healthy subjects. Saliva has a high potential for keeping track of general health and diseases. AD is a type of dementia with reduction in brain cholinergic markers that causes memory, thinking, and behavior problems. Up to 90% decrease in AChE activity has been observed in AD.
METHODS AND RESULTS
Thirty healthy subjects and 30 patients with AD participated in this study. Saliva samples were collected from 8 to 10 am. AChE and PChE of saliva were assessed by the Ellman method. Statistical comparison was performed using SPSS 16 for t-test. The activity of AChE and PChE significantly increased in the group with AD compared to the healthy subjects. Sex had no effect on the activities of these enzymes. No correlation existed between the duration of illness and enzymatic activity. The enzyme levels reduced with age.
CONCLUSION
AChE and PChE levels were increased in saliva samples of patients with AD. Therefore, saliva has the potential for being used for the purpose of biomarker evaluation to replace cerebrospinal fluid in patients with AD.
DOI: 10.1111/scd.12342
PubMed: 30536408
Affiliations:
Links toward previous steps (curation, corpus...)
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xml:lang="fr">Iran</country><wicri:regionArea>Associate professor, Dental Implant Research Center, Department of Oral Medicine, Dental School, Hamadan University of Medical Sciences, Hamadan</wicri:regionArea><wicri:noRegion>Hamadan</wicri:noRegion></affiliation></author><author><name sortKey="Goodarzi, Mohammad Taghi" sort="Goodarzi, Mohammad Taghi" uniqKey="Goodarzi M" first="Mohammad Taghi" last="Goodarzi">Mohammad Taghi Goodarzi</name><affiliation wicri:level="1"><nlm:affiliation>Professor, Research Center for Molecular Medicine, Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Professor, Research Center for Molecular Medicine, Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan</wicri:regionArea><wicri:noRegion>Hamadan</wicri:noRegion></affiliation></author><author><name sortKey="Tarazi, Shabnam" sort="Tarazi, Shabnam" uniqKey="Tarazi S" first="Shabnam" last="Tarazi">Shabnam Tarazi</name><affiliation wicri:level="1"><nlm:affiliation>General Dental Practitioner, Hamadan University of Medical Sciences, Hamadan, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>General Dental Practitioner, Hamadan University of Medical Sciences, Hamadan</wicri:regionArea><wicri:noRegion>Hamadan</wicri:noRegion></affiliation></author><author><name sortKey="Vahabian, Mehrangiz" sort="Vahabian, Mehrangiz" uniqKey="Vahabian M" first="Mehrangiz" last="Vahabian">Mehrangiz Vahabian</name><affiliation wicri:level="1"><nlm:affiliation>Assistant Professor of Linguistics, Department of Persian Literature and English Language, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.</nlm:affiliation><country xml:lang="fr">Iran</country><wicri:regionArea>Assistant Professor of Linguistics, Department of Persian Literature and English Language, School of Medicine, Hamadan University of Medical Sciences, Hamadan</wicri:regionArea><wicri:noRegion>Hamadan</wicri:noRegion></affiliation></author></analytic><series><title level="j">Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry</title><idno type="eISSN">1754-4505</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholinesterase (metabolism)</term><term>Aged (MeSH)</term><term>Aged, 80 and over (MeSH)</term><term>Alzheimer Disease (enzymology)</term><term>Butyrylcholinesterase (metabolism)</term><term>Case-Control Studies (MeSH)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Middle Aged (MeSH)</term><term>Saliva (enzymology)</term><term>Surveys and Questionnaires (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acetylcholinesterase (métabolisme)</term><term>Adulte d'âge moyen (MeSH)</term><term>Butyrylcholine esterase (métabolisme)</term><term>Enquêtes et questionnaires (MeSH)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Maladie d'Alzheimer (enzymologie)</term><term>Mâle (MeSH)</term><term>Salive (enzymologie)</term><term>Sujet âgé (MeSH)</term><term>Sujet âgé de 80 ans ou plus (MeSH)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Acetylcholinesterase</term><term>Butyrylcholinesterase</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Maladie d'Alzheimer</term><term>Salive</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Alzheimer Disease</term><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acetylcholinesterase</term><term>Butyrylcholine esterase</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Enquêtes et questionnaires</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>AIM</b></p><p>The aim of this study was to evaluate acetylcholinesterase (AChE) and pseudocholinesterase (PChE) in whole saliva in patients with Alzheimer's disease (AD) and in healthy subjects. Saliva has a high potential for keeping track of general health and diseases. AD is a type of dementia with reduction in brain cholinergic markers that causes memory, thinking, and behavior problems. Up to 90% decrease in AChE activity has been observed in AD.</p></div><div type="abstract" xml:lang="en"><p><b>METHODS AND RESULTS</b></p><p>Thirty healthy subjects and 30 patients with AD participated in this study. Saliva samples were collected from 8 to 10 am. AChE and PChE of saliva were assessed by the Ellman method. Statistical comparison was performed using SPSS 16 for t-test. The activity of AChE and PChE significantly increased in the group with AD compared to the healthy subjects. Sex had no effect on the activities of these enzymes. No correlation existed between the duration of illness and enzymatic activity. The enzyme levels reduced with age.</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSION</b></p><p>AChE and PChE levels were increased in saliva samples of patients with AD. Therefore, saliva has the potential for being used for the purpose of biomarker evaluation to replace cerebrospinal fluid in patients with AD.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30536408</PMID><DateCompleted><Year>2019</Year><Month>05</Month><Day>31</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1754-4505</ISSN><JournalIssue CitedMedium="Internet"><Volume>39</Volume><Issue>1</Issue><PubDate><Year>2019</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry</Title><ISOAbbreviation>Spec Care Dentist</ISOAbbreviation></Journal><ArticleTitle>Evaluation of salivary acetylcholinesterase and pseudocholinesterase in patients with Alzheimer's disease: A case-control study.</ArticleTitle><Pagination><MedlinePgn>39-44</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/scd.12342</ELocationID><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">The aim of this study was to evaluate acetylcholinesterase (AChE) and pseudocholinesterase (PChE) in whole saliva in patients with Alzheimer's disease (AD) and in healthy subjects. Saliva has a high potential for keeping track of general health and diseases. AD is a type of dementia with reduction in brain cholinergic markers that causes memory, thinking, and behavior problems. Up to 90% decrease in AChE activity has been observed in AD.</AbstractText><AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">Thirty healthy subjects and 30 patients with AD participated in this study. Saliva samples were collected from 8 to 10 am. AChE and PChE of saliva were assessed by the Ellman method. Statistical comparison was performed using SPSS 16 for t-test. The activity of AChE and PChE significantly increased in the group with AD compared to the healthy subjects. Sex had no effect on the activities of these enzymes. No correlation existed between the duration of illness and enzymatic activity. The enzyme levels reduced with age.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">AChE and PChE levels were increased in saliva samples of patients with AD. Therefore, saliva has the potential for being used for the purpose of biomarker evaluation to replace cerebrospinal fluid in patients with AD.</AbstractText><CopyrightInformation>© 2018 Special Care Dentistry Association and Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ahmadi-Motamayel</LastName><ForeName>Fatemeh</ForeName><Initials>F</Initials><Identifier Source="ORCID">https://orcid.org/0000-0002-7138-7690</Identifier><AffiliationInfo><Affiliation>Associate professor, Dental Implant Research Center, Department of Oral Medicine, Dental School, Hamadan University of Medical Sciences, Hamadan, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goodarzi</LastName><ForeName>Mohammad Taghi</ForeName><Initials>MT</Initials><AffiliationInfo><Affiliation>Professor, Research Center for Molecular Medicine, Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tarazi</LastName><ForeName>Shabnam</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>General Dental Practitioner, Hamadan University of Medical Sciences, Hamadan, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vahabian</LastName><ForeName>Mehrangiz</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Assistant Professor of Linguistics, Department of Persian Literature and English Language, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Hamadan University of Medical Sciences</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>12</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Spec Care Dentist</MedlineTA><NlmUniqueID>8103755</NlmUniqueID><ISSNLinking>0275-1879</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 3.1.1.7</RegistryNumber><NameOfSubstance UI="D000110">Acetylcholinesterase</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.1.8</RegistryNumber><NameOfSubstance UI="D002091">Butyrylcholinesterase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000110" MajorTopicYN="N">Acetylcholinesterase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000544" MajorTopicYN="N">Alzheimer Disease</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002091" MajorTopicYN="N">Butyrylcholinesterase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Alzheimer's disease</Keyword><Keyword MajorTopicYN="N">cholinesterases</Keyword><Keyword MajorTopicYN="N">saliva</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year><Month>05</Month><Day>01</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2018</Year><Month>09</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>10</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>12</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>6</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>12</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30536408</ArticleId><ArticleId IdType="doi">10.1111/scd.12342</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Ahmadi Motamayel, Fatemeh" sort="Ahmadi Motamayel, Fatemeh" uniqKey="Ahmadi Motamayel F" first="Fatemeh" last="Ahmadi-Motamayel">Fatemeh Ahmadi-Motamayel</name></noRegion><name sortKey="Goodarzi, Mohammad Taghi" sort="Goodarzi, Mohammad Taghi" uniqKey="Goodarzi M" first="Mohammad Taghi" last="Goodarzi">Mohammad Taghi Goodarzi</name><name sortKey="Tarazi, Shabnam" sort="Tarazi, Shabnam" uniqKey="Tarazi S" first="Shabnam" last="Tarazi">Shabnam Tarazi</name><name sortKey="Vahabian, Mehrangiz" sort="Vahabian, Mehrangiz" uniqKey="Vahabian M" first="Mehrangiz" last="Vahabian">Mehrangiz Vahabian</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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